Study on secondary metabolites of endophytic fungus Cladosporium sp. JJM22 hosted in Ceriops tagal.
10.19540/j.cnki.cjcmm.20201223.601
- Author:
Zhen LI
1
;
Jing-Yu YANG
1
;
Jin CAI
1
;
Zi-Juan OUYANG
1
;
Chu-Han ZHOU
1
;
Guang-Ying CHEN
1
;
Xue-Ming ZHOU
1
Author Information
1. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University Haikou 571158, China.
- Publication Type:Journal Article
- Keywords:
Cladosporium;
endophytic fungus;
inhibition on NO production;
secondary metabolites
- MeSH:
Animals;
Benzopyrans;
Cladosporium;
Fungi;
Mice;
Molecular Structure;
Rhizophoraceae
- From:
China Journal of Chinese Materia Medica
2021;46(8):2079-2083
- CountryChina
- Language:Chinese
-
Abstract:
Nine secondary metabolites(S)-5-hydroxy-4-methylchroman-2-one(1), 4-methoxynaphthalene-1,5-diol(2), 8-methoxynaphthalene-1,7-diol(3), 1,8-dimethoxynaphthalene(4),(2R,4S)-2,3-dihydro-2-methyl-benzopyran-4,5-diol(5),(2R,4R)-3,4-dihydro-4-methoxy-2-methyl-2H-1-benzopyran-5-ol(6), 7-O-α-D-ribosyl-2,3-dihydro-5-hydroxy-2-methyl-chromen-4-one(7),(R)-3-methoxyl-1-(2,6-dihydroxyphenyl)-butan-1-one(8) and helicascolide A(9) were isolated from endophytic fungus Cladosporium sp. JJM22 by using column chromatographies of silica gel and ODS, and semi-preparative HPLC. Their structures were analyzed on the basis of spectroscopic and chemical data, especially NMR and MS. All isolated compounds were evaluated for their anti-inflammatory activities by examining the inhibitory activities on nitric oxide(NO) production induced by lipopolysaccharide in mouse macrophage RAW264.7 cells in vitro. Compounds 2-4 showed inhibitory activities.
