A new lignan from Euscaphis konishii.
10.19540/j.cnki.cjcmm.20200629.201
- Author:
Jing-Xin CHEN
1
;
Lin NI
2
;
Yao ZHANG
1
;
Jia-Rui FU
1
;
Wei HUANG
3
;
Shuang-Quan ZOU
3
Author Information
1. College of Plant Protection, Fujian Agriculture and Forestry University Fuzhou 350002, China.
2. College of Plant Protection, Fujian Agriculture and Forestry University Fuzhou 350002, China Fujian Colleges and Universities Engineering Research Institute of Conservation & Utilization of Natural Bioresources Fuzhou 350002, China.
3. Fujian Colleges and Universities Engineering Research Institute of Conservation & Utilization of Natural Bioresources Fuzhou 350002, China.
- Publication Type:Journal Article
- Keywords:
Euscaphis konishii;
anti-hepatoma;
chemical constituent;
konilignan;
lignans
- MeSH:
Chromatography, High Pressure Liquid;
Lignans/pharmacology*;
Plant Extracts/pharmacology*
- From:
China Journal of Chinese Materia Medica
2021;46(8):2072-2078
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents from the extract of the twigs of Euscaphis konishii with anti-hepatoma activity were investigated, twelve compounds by repeated chromatography with silica gel, Sephadex LH-20 and preparative-HPLC. The structures of the chemical components were elucidated by spectroscopy methods, as konilignan(1),(7R, 8S)-dihydrodehydrodico-niferylalcohol-9-O-β-D-glucopyranoside(2),illiciumlignan B(3),threo-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-panediol(4),erythro-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-panediol(5), matairesinol(6), wikstromol(7), isolariciresinol(8),(+)-lyoniresinol(9), 4-ketopinoresinol(10), syringaresin(11), and vladinol D(12). Among them, compound 1 is a new lignan. Compounds 10 and 12 had moderate inhibitory activity on HepG2 cells, with IC_(50) values of 107.12 μmol·L~(-1) and 183.56 μmol·L~(-1), respectively.
