Germacrene-derived sesquiterpene lactones:opportunities and challenges for biosynthesis.
10.19540/j.cnki.cjcmm.20201230.602
- Author:
Qiang ZHANG
1
;
Dong-Mei XIE
2
;
Lei ZHANG
3
;
Guo-Kai WANG
1
Author Information
1. School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China.
2. School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China Institute of Traditional Chinese Medicine Resources Protection and Development, Anhui Academy of Chinese Medicine Hefei 230012, China.
3. Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University Shanghai 200433, China.
- Publication Type:Journal Article
- Keywords:
biosynthesis;
functional gene;
germacrene-derived sesquiterpene lactones;
key enzymes
- MeSH:
Biosynthetic Pathways;
Lactones;
Sesquiterpenes
- From:
China Journal of Chinese Materia Medica
2021;46(8):2020-2028
- CountryChina
- Language:Chinese
-
Abstract:
Sesquiterpene lactones are a kind of widely distributed natural organic compounds with anti-tumor, anti-malarial and other significant biological activities. Based on their carbocylic skeletons, sesquiterpene lactones are classified into germacranolide, guaia-nolide, xanthanolide, pseudo-guaianolide, elemonolide and eudesmanolide, etc. In recent years, with the development of various omics and synthetic biology technologies, the biosynthetic pathways of sesquiterpene lactone compounds of different structural types have gradually been resolved. Among them, the researches on germacrene-derived sesquiterpene lactones are relatively more than others. Therefore, this article focused on the germacrene-derived sesquiterpene lactone biosynthesis pathways and their key enzyme genes, which can lay the foundation for in-depth analysis of sesquiterpene lactone biosynthetic pathways, functional gene mining and heterologous synthesis of active ingredients.
