Study on chemical constituents from fruiting bodies of Ganoderma calidophilum.
10.19540/j.cnki.cjcmm.20201223.602
- Author:
Ting-Ting ZHANG
1
;
Jiao-Cen GUO
2
;
Qing-Yun MA
2
;
Fan-Dong KONG
2
;
Li-Man ZHOU
2
;
Qing-Yi XIE
2
;
Hao-Fu DAI
3
;
Zhi-Fang YU
4
;
You-Xing ZHAO
2
Author Information
1. College of Food Science and Technology, Nanjing Agricultural University Nanjing 210095, China Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences Haikou 571101, China.
2. Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences Haikou 571101, China.
3. Hainan Academy of Tropical Agricultural Resource, Chinese Academy of Tropical Agricultural Sciences Haikou 571101, China.
4. College of Food Science and Technology, Nanjing Agricultural University Nanjing 210095, China.
- Publication Type:Journal Article
- Keywords:
Ganoderma calidophilum;
chemical constituents;
cytotoxic activity
- MeSH:
Cell Line, Tumor;
Fruiting Bodies, Fungal;
Ganoderma;
Molecular Structure;
Triterpenes/pharmacology*
- From:
China Journal of Chinese Materia Medica
2021;46(7):1783-1789
- CountryChina
- Language:Chinese
-
Abstract:
Chemical constituents were isolated and purified from fruiting bodies of Ganoderma calidophilum by various column chromatographic techniques, and their chemical structures were identified through combined analysis of physicochemical properties and spectral data. As a result, 11 compounds were isolated and identified as(24E)-lanosta-8,24-dien-3,11-dione-26-al(1), ganoderone A(2), 3-oxo-15α-acetoxy-lanosta-7,9(11), 24-trien-26-oleic acid(3),(23E)-27-nor-lanosta-8,23-diene-3,7,25-trione(4), ganodecanone B(5), ganoderic aldehyde A(6), 11β-hydroxy-lucidadiol(7), 3,4-dihydroxyacetophenone(8), methyl gentiate(9), ganoleucin C(10), ganotheaecolumol H(11). Among them, compound 1 is a new triterpenoid. The cytotoxic activities of all of the compounds against tumor cell lines were evaluated. The results showed that compounds 1, 3, 4 and 6 showed cytotoxic activity against BEL-7402, with IC_(50) values of 26.55, 11.35, 23.23, 18.66 μmol·L~(-1); compounds 1 and 3-6 showed cytotoxic activity against K562, with IC_(50) values of 5.79, 22.16, 12.16, 35.32, and 5.59 μmol·L~(-1), and compound 4 showed cytotoxic activity against A549, with IC_(50) value of 42.50 μmol·L~(-1).
