Advance on pharmacokinetics study of traditional Chinese medicine injections in recent ten years.
10.19540/j.cnki.cjcmm.20201204.601
- Author:
Yuan-Rong LIU
1
;
Shu-Yu ZHAN
1
;
Bo-Hong ZHENG
1
;
Meng-Ting FANG
1
;
Yi-Han FENG
1
;
Jie ZHANG
1
;
Ming-Juan LI
1
;
Bao-Yue DING
1
Author Information
1. Medical College of Jiaxing University Jiaxing 314001, China.
- Publication Type:Journal Article
- Keywords:
analysis technique;
clinical pharmacokinetics;
pharmacokinetic interactions;
pharmacokinetics;
traditimal Chinese medicine(TCM) injection
- MeSH:
Drugs, Chinese Herbal;
Injections;
Medicine, Chinese Traditional;
Quality Control
- From:
China Journal of Chinese Materia Medica
2021;46(7):1752-1762
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine(TCM) injections boast a definite efficacy and have been widely used in clinic. However, the problems in medication safety have been attracted increasing attention. Pharmacokinetics is of significance to guiding TCM injection administration regimen design and improving safety and effectiveness in clinical use. In recent years, with the improvement of ideas, technology and methods of TCM studies, the pharmacokinetic studies of TCM injections have been broadly performed, with a notable progress. This paper reviewed the advance in pharmacokinetics studies of TCM injections in recent ten years, which mainly focused on pre-clinical concentration-time course, distribution, metabolism and excretion in vivo based on analysis techniques, pharmacokinetic interactions of constitutes, impact of pathological state, pharmacokinetic interactions between TCM injection and chemical drugs, and clinical pharmacokinetics studies of TCM injections, in the expectation of providing reference for studies on quality control, product development and rational clinical use of TCM injections.
