Research progress on bidirectional effect of microRNA on Alzheimer's disease and intervention with traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20201201.601
- Author:
Li-Li GU
1
;
Qin LI
1
;
Ning-Zi WU
1
;
Jia-Qi LU
1
;
Hong-Xing LI
1
;
Xin-Yue ZHANG
1
Author Information
1. Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College Hangzhou 310013, China.
- Publication Type:Journal Article
- Keywords:
Alzheimer′s disease;
microRNA;
neuroprotection;
neurotoxicity;
traditional Chinese medicine
- MeSH:
Alzheimer Disease/genetics*;
Humans;
Medicine, Chinese Traditional;
MicroRNAs/genetics*;
Neurodegenerative Diseases
- From:
China Journal of Chinese Materia Medica
2021;46(7):1743-1751
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD) is a chronic progressive neurodegenerative disease with recent memory impairment as the main clinical manifestation and senile plaques and neurofibrillary tangles as the main pathological changes. In recent years, the effect of microRNAs on AD has attracted widespread attention. Patients with AD have abnormal expression of miRNA, which is closed related to regulation of AD pathophysiology-related genes. Therefore, this paper first elaborated neuroprotective and toxic effects of microRNA in AD, and then explored relevant traditional Chinese medicines that can regulate miRNA in the treatment of AD, so as to provide basis for revealing the pathogenesis relationship between miRNA and AD and provide ideas for further development of anti-AD traditional Chinese medicine.
