Critical quality attribute assessment of big brand traditional Chinese medicine: quality control method of Huangjing Zanyu Capsules based on chemical properties of characteristic components.
10.19540/j.cnki.cjcmm.20210205.303
- Author:
Jin-Yuan ZHU
1
;
Jing-Qi ZENG
1
;
Qian-Qian LI
1
;
Li-Juan MA
1
;
Ying LU
1
;
Han ZHANG
1
;
Yan-Fei ZHENG
2
;
Chun-Yuan WU
3
;
Zhi-Sheng WU
1
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China Engineering Research Center of Chinese Medicine Production and New Drug Development, Ministry of Education Beijing 102488, China.
2. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 100029, China.
3. Shanghai New Asiatic Pharmaceuticals Hanjiang Co., Ltd. Yangzhou 225100, China.
- Publication Type:Journal Article
- Keywords:
Huangjing Zanyu Capsules;
big brand traditional Chinese medicine;
chemical properties of characteristic components;
critical quality attribute;
interval estimation method;
multivariate statistical process control
- MeSH:
Capsules;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
Medicine, Chinese Traditional;
Quality Control
- From:
China Journal of Chinese Materia Medica
2021;46(7):1629-1635
- CountryChina
- Language:Chinese
-
Abstract:
The chemical properties of characteristic components are significant to the manufacturing quality control of big brand traditional Chinese medicine. In this study, the Huangjing Zanyu Capsules were used as the research carrier to determine the content of five characteristic components including icraiin, emodin, schisandrin A, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, and osthole simultaneously by high-performance liquid chromatography(HPLC). The results showed that the chemical properties of five cha-racteristic components had a good linear relationship(r>0.999 9) within the quantitative range; the relative standard deviations(RSD) was 0.11%-2.0% and 0.25%-2.8% respectively for intra-day and inter-day precision; the RSD of repeatability was 1.8%-2.6%; the RSD of stability within 48 hours was 0.19%-2.8%, and the average recovery rate was 95.52%-100.1%, all meeting the requirements of pharmaceutical quantitative analysis. Additionally, the interval estimation method was used to directly reflect the distribution of samples with abnormal chemical properties of characteristic components, and the results showed ten samples were detected beyound the 95% control line of confidence level. Multivariate statistical process control(MSPC) method was used to monitor the abnormal samples of Huangjing Zanyu Capsules collectively, and the results showed that two samples were beyond the 95% control line of Hotelling's T~2 and three samples beyond the 95% control line of squared prediction error(SPE), indicating consistent quality control of Huangjing Zanyu Capsules. In conclusion, the proposed method is not only accurate and efficient but also a compensation for the traditional single-component quality control method, providing a scientific basis for the quality control in manufacturing process of Huangjing Zanyu Capsules. Furthermore, it could also serve as a reference method for the quality control in manufacturing big brand traditional Chinese medicine.
