Studies on phenylpropanoids from Eleocharis dulcis and their hepatoprotective activities.
10.19540/j.cnki.cjcmm.20200821.201
- Author:
Rong-Rui WEI
1
;
Qin-Ge MA
1
;
Zhi-Pei SANG
2
;
Jiang-Hong DONG
3
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education & Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China.
2. College of Chemistry and Pharmaceutical Engineering,Nanyang Normal University Nanyang 473061,China.
3. College of Chemistry and Pharmaceutical Engineering,Huanghuai University Zhumadian 463000,China.
- Publication Type:Journal Article
- Keywords:
Heleocharis dulcis;
hepatoprotective activity;
phenylpropanoid
- MeSH:
Chromatography;
Eleocharis;
Hepatocytes;
Plant Extracts
- From:
China Journal of Chinese Materia Medica
2021;46(6):1430-1437
- CountryChina
- Language:Chinese
-
Abstract:
To study phenylpropanoids from Eleocharis dulcis and their hepatoprotective activities. The compounds were separated and purified from ethyl acetate part by conventional column chromatography and preparative liquid chromatography, and their structures were identified by various spectral techniques. The HL-7702 cells damage model of hepatocytes induced by APAP was used to screen and evaluate the hepatoprotective activities of these compounds. Sixteen compounds were isolated from ethyl acetate part of E. dulcis, and their structures were identified as 6'-(4″-hydroxy-3″-methoxy-phenylpropenyl)-1-(10-methoxy-phenylacetone)-1'-O-β-D-glucopy-ranoside(1), susaroyside A(2), clausenaglycoside B(3), clausenaglycoside C(4), clausenaglycoside D(5), emarginone A(6), emarginone B(7), thoreliin B(8), 4-O-(1',3'-dihydroxypropan-2'-yl)-dihydroconiferyl alcohol 9-O-β-D-glucopyranoside(9), 2-[4-(3-methoxy-1-propenyl)-2-methoxy-phenoxy]-propane-1,3-diol(10), 6'-O-(E-cinnamoyl)-coniferin(11), methyl 3-(2-O-β-D-glucopyranosyl-3,4,5,6-tetramethoxyphenyl) propanoate(12), clausenaglycoside A(13), 9-O-(E-cinnamoyl)-coniferin(14), 6'-O-(E-cinnamoyl)-syringin(15), 2'-O-(E-cinnamoyl)-syringin(16). Among them, compound 1 was a new compound. Compounds 2-16 were isolated from this plant for the first time. Among them, compounds 2 and 8 showed certain hepatoprotective activities.
