Relationship between programmed cell death and myocardial ischemia-reperfusion injury and new perspectives of traditional Chinese medicine intervention.
10.19540/j.cnki.cjcmm.20201222.601
- Author:
Yan-Zheng XIE
1
;
Jin MA
1
;
Geng-Zhen YAO
2
;
Xu ZOU
2
Author Information
1. the Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510000,China Guangdong Provincial Key laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou 510000,China.
2. the Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510000,China.
- Publication Type:Journal Article
- Keywords:
myocardial ischemia-reperfusion injury;
programmed cell death;
traditional Chinese medicine
- MeSH:
Apoptosis;
China;
Humans;
Medicine, Chinese Traditional;
Myocardial Reperfusion Injury/genetics*;
Myocytes, Cardiac
- From:
China Journal of Chinese Materia Medica
2021;46(6):1345-1356
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial ischemia-reperfusion injury(MIRI) is an urgent problem in clinical treatment. As cardiomyocytes are terminal cells, MIRI-induced cardiomyocyte death will irreversibly damage the structure and function of the heart. In previous studies, apoptosis was considered to be the only way to regulate cell death, while necrosis could not be regulated. However, current studies have shown that cell necrosis could also be regulated, which was collectively called programmed cell death(PCD). Regulated cell death is actively mediated through molecular pathways, so there is the possibility of inhibiting this signaling to reduce MIRI. At present, PCD mainly includes apoptosis, autophagy, necrosis, pyroptosis and ferroptosis. As a unique treature in China, traditional Chinese medicine has the advantages of multiple pathways, multiple targets, low toxicity, less side effects and low economic costs. With the in-depth study of the efficacy of traditional Chinese medicine against MIRI, it has been confirmed that traditional Chinese medicine could regulate PCD to reduce MIRI. Therefore, this paper focuses on the relationship between PCD and MIRI, and new studies on intervention with relevant traditional Chinese medicine, with the aim to provide new MIRI prevention and treatment methods from the perspective of "intervention of PCD".
