Systematic review of randomized controlled trial of Maxing Shigan Decoction in treatment of community acquired pneumonia.
10.19540/j.cnki.cjcmm.20200714.501
- Author:
Kai LI
1
;
Feng-Wen YANG
1
;
Wen-Tai PANG
1
;
Hui-Zi CAI
1
;
Ming-Yan ZHANG
1
;
Jun-Hua ZHANG
1
Author Information
1. Evidence-based Medicine Center,Tianjin University of Traditional Chinese Medicine Tianjin 300193,China.
- Publication Type:Systematic Review
- Keywords:
Maxing Shigan Decoction;
community acquired pneumonia;
randomized controlled trial;
systematic review
- MeSH:
Community-Acquired Infections/drug therapy*;
Cough;
Drugs, Chinese Herbal;
Humans;
Pneumonia/drug therapy*;
Randomized Controlled Trials as Topic;
Treatment Outcome
- From:
China Journal of Chinese Materia Medica
2021;46(5):1268-1275
- CountryChina
- Language:Chinese
-
Abstract:
To systemically evaluate the efficacy and safety of Maxing Shigan Decoction in the treatment of community acquired pneumonia(CAP) and provide a reference for the treatment of CAP. Databases of CNKI, Wanfang, VIP, SinoMed, EMbase, Cochrane Library, Web of Science and PubMed were searched(from inception to May 30, 2020) to screen the randomized controlled trials(RCTs) of Maxing Shigan Decoction in treating CAP. Two authors independently screened and selected relevant literature and extracted data based on the inclusion and exclusion criteria. Any disagreement or differences was resolved through discussion. The bias risk assessment tool recommended by Cochrane handbook was used to evaluate the quality of the included studies, and RevMan 5.3 software was used for data analysis. Seventeen RCTs were finally included, involving 1 309 patients. Meta-analysis showed that Maxing Shigan Decoction combined with conventional Western medicine treatment could improve clinical efficacy in patients with CAP more effectively as compared with conventional Western medicine treatment alone, mainly in terms of anti-inflammatory effects, a decrease in C-reactive protein(CRP) content(MD=-6.01, 95%CI[-10.95,-1.06], P=0.02)and white blood cell(WBC) count, a decrease in procalcitonin(PCT) level(MD=-0.74, 95%CI[-0.77,-0.71], P<0.000 1), and shortened recovery time of cough and fever. Maxing Shigan Decoction has certain curative effect on CAP, but there are problems in the methodology of included studies. High-quality stu-dies are still needed for further verification.
