Research on chemical constituents from Artemisia annua Ⅰ.
10.19540/j.cnki.cjcmm.20210107.601
- Author:
Li-Hao XIAO
1
;
Hai-Bo LI
1
;
Yu-Xin HUANG
2
;
Da-Peng QIN
3
;
Chen-Feng ZHANG
1
;
Zhen-Zhong WANG
1
;
Yang YU
2
Author Information
1. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process,Kanion Pharmaceutical Co.,Ltd. Lianyungang 222001,China.
2. Institute of Traditional Chinese Medicine and Natural Products,College of Pharmacy,Jinan University Guangzhou 510632,China.
3. School of Pharmaceutical Sciences,Shenzhen University Health Science Center Shenzhen 518060,China.
- Publication Type:Journal Article
- Keywords:
Artemisia annua;
PGE_2;
chemical constituents;
structure elucidation
- MeSH:
Apigenin;
Artemisia annua;
Quercetin;
Rutin
- From:
China Journal of Chinese Materia Medica
2021;46(5):1160-1167
- CountryChina
- Language:Chinese
-
Abstract:
Chemical constituents were isolated and purified from the water extract of Artemisia annua by column chromatography of HP-20 macroporous resin, silica gel, ODS, Sephadex LH-20, HW-40, and semi-preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analyses. As a result, Fifteen compounds were isolated and identified as vitexnegheteroin M(1), sibricose A5(2), securoside A(3), citrusin D(4), annphenone(5), E-melilotoside(6), esculetin(7), scopoletin-7-O-β-D-glucoside(8), eleutheroside B_1(9), chrysosplenol D(10), patuletin-3-O-β-D-glucopyranoside(11), quercetin-7-O-β-D-glucoside(12), rutin(13), apigenin 6,8-di-C-β-D-glucopyranoside(14), isoschaftoside(15), among them, compounds 1-4 were identified from Artemisia for the first time. Additionally, the isolates were evaluated for their inhibitory effects on the production of PGE_2 in LPS-simulated RAW264.7 macrophages. The results showed that compounds 1, 2, 8, and 10-15 could reduce PGE_2 levels, to a certain extent.
