Research ideas and method on screening active components of traditional Chinese medicine against hepatotoxicity with mitochondria as target.
10.19540/j.cnki.cjcmm.20200904.601
- Author:
Yu-Lin WANG
1
;
Yu-Ting LIU
1
;
Yan-Yan TAO
2
;
Cheng-Hai LIU
2
;
Hui-Yan QU
3
;
Hua ZHOU
3
;
Tao YANG
1
Author Information
1. Institute of Cardiovascular Disease, Department of Cardiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Shanghai Key Laboratory of Traditional Chinese Clinical Medicine Shanghai 201203, China.
2. Institute of Liver Diseases, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Shanghai Key Laboratory of Traditional Chinese Clinical Medicine Shanghai 201203, China.
3. Institute of Cardiovascular Disease, Department of Cardiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
- Publication Type:Review
- Keywords:
active ingredients;
drug-induced liver injury;
mitochondria;
mitochondrial autophagy;
traditional Chinese medicine
- MeSH:
Chemical and Drug Induced Liver Injury;
Drug-Related Side Effects and Adverse Reactions;
Drugs, Chinese Herbal/toxicity*;
Humans;
Medicine, Chinese Traditional;
Mitochondria
- From:
China Journal of Chinese Materia Medica
2021;46(2):306-311
- CountryChina
- Language:Chinese
-
Abstract:
Liver is the main place of drug metabolism. Mitochondria of hepatocytes are important targets of drug-induced liver injury. Mitochondrial autophagy could maintain the healthy operation of mitochondria in cells and the stable proliferation of cells. Therefore, the use of mitochondrial autophagy to remove damaged mitochondria is an important strategy of anti-drug-induced liver injury. Active ingredients that could enhance mitochondrial autophagy are contained in many traditional Chinese medicines, which could regulate the mitochondrial autophagy to alleviate relevant diseases. However, there are only a few reports on how to accurately and efficiently identify and evaluate such components targeting mitochondria from traditional Chinese medicine. Liquid chromatography-mass spectro-metry(LC-MS) combined with serum pharmacology in vivo can be used to accurately and efficiently find active ingredients of traditional Chinese medicine acting on mitochondrial targets. This paper reviewed the research ideas and methods of traditional Chinese medicine ingredients for increasing the hepatotoxicity of mitochondrial autophagy, in order to provide new ideas and methods for the study of active ingredients of traditional Chinese medicine targeting mitochondria.
