Analysis on quality value transfer of substance benchmarks of Zhenwu Decoction.
10.19540/j.cnki.cjcmm.20201118.301
- Author:
Yu-Ming ZHANG
1
;
Shou-Ying DU
1
;
Jie BAI
1
;
Yang LU
1
;
Ning HAN
1
Author Information
1. School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 102488,China.
- Publication Type:Journal Article
- Keywords:
Zhenwu Decoction;
characteristic spectrum;
classical prescription;
quantity value transfer;
substance benchmarks
- MeSH:
Benchmarking;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
Quality Control
- From:
China Journal of Chinese Materia Medica
2021;46(4):820-829
- CountryChina
- Language:Chinese
-
Abstract:
By preparing 15 batches of Zhenwu Decoction substance benchmarks,the characteristic map,index component content and paste-forming rate were determined to define the peak attribution,similarity range,paste-forming rate range,paeoniflorin and6-gingerol content range and transfer rate range. The similarity between the substance benchmark characteristic map and the control map R generated from the 15 batches of substance benchmarks was higher than 0. 970. There were 19 characteristic peaks in total. By further summarization of the characteristic peaks,it could be seen that tuckahoe had 3 characteristic peaks,white peony root had 10 characteristic peaks,atractylodes had 3 characteristic peaks,ginger had 1 characteristic peak,and Aconite root had 3 characteristic peaks; among them,white peony root and aconite root had 1 common peak. The contents and transfer rates of the 15 batches were0. 50%-0. 93 and 16. 11%-26. 20%; those for 6-gingerol were 0. 018 2%-0. 033 9% and 13. 16%-24. 10%,respectively. The pasteforming rate ranged from 10. 00% to 14. 85%. In this study,the transfer process of substance benchmark value of classic formula Zhenwu Decoction was analyzed based on the characteristic map,the paste-forming rate and the content of the index components; a scientific and stable substance benchmark quality evaluation method was preliminarily established to provide a basis for subsequent development of classic formula Zhenwu Decoction and quality control of relevant preparations.
