Analysis on quality value transmitting of substance benchmark of Houpo Wenzhong Decoction.
10.19540/j.cnki.cjcmm.20201130.302
- Author:
Qing ZHANG
1
;
Ju-Yuan LUO
1
;
Wen-Jun HU
1
;
Ruo-Nan SHEN
1
;
Xue-Chun LIU
1
;
Yue-Ying ZHAO
1
;
Xing-Yue HUANG
1
;
Chang-Hai WANG
1
;
Ze-Kang ZHANG
1
;
Yang LU
2
;
Ning HAN
1
;
Wen-Yan ZHOU
3
Author Information
1. Beijing University of Chinese Medicine,School of Chinese Materia Medica Beijing 102488,China.
2. Beijing University of Chinese Medicine,School of Chinese Materia Medica Beijing 102488,China Shenzhen Research Institute Beijing University of Chinese Medicine Shenzhen 518000,China.
3. Yifan Pharmaceutical Co.,Ltd. Lin'an 311300,China.
- Publication Type:Journal Article
- Keywords:
Houpo Wenzhong Decoction;
characteristic spectrum;
classical prescription;
quality value transmitting;
substance benchmark
- MeSH:
Benchmarking;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
Glycyrrhiza;
Quality Control
- From:
China Journal of Chinese Materia Medica
2021;46(4):810-819
- CountryChina
- Language:Chinese
-
Abstract:
By preparing 15 batches of lyophilized powder samples of substance benchmark in Houpo Wenzhong Decoction,the fingerprint,index component content and extract rate were determined,and the characteristic peaks,the range of similarity with the reference map,the content range and transfer rate range of magnolol,hesperidin,glycyrrhizic acid and pinocembrin,the extract rate range and the change range were clarified. The results showed that the similarity between the fingerprint of substance benchmark and the reference map R generated from the 15 batches of substance benchmark samples was higher than 0. 90. The assignment of the characteristic peaks in the full prescription's fingerprint of the herbs except Poria cocos was clarified. Nineteen characteristic peaks were assigned,and 12 characteristic peaks were assigned by the reference substance,of which 4 were from Magnolia ocinalis Cortex,5 from Exocarpium Citri Rubrum,2 from Radix aucklandiae,3 from Glycyrrhiza Radix et Rhizoma,4 from Semen Alpiniae Katsumadai,and one from Rhizoma Zingiberis and Zingiber officinale Roscoe. The index component content range and transfer rate range were 0. 80%-1. 14% and 20. 25%-39. 61% for hesperidin,0. 49%-0. 79% and 23. 09%-33. 87%for glycyrrhizic acid,0. 03%-0. 07% and 3. 55%-10. 09% for pinocembrin,0. 15%-0. 38% and 8. 08%-24. 35% for magnolol. The extract rate range and the change range were22. 60%-25. 57% and 12. 67%-23. 68% respectively. In this study,we introduced the concepts of index component content,fingerprint,extract rate,explored the transfer relation of quality value transmitting of substance benchmark in Houpo Wenzhong Decoction,and initially established the quality standard of Houpo Wenzhong Decoction,all of which would provide ideas for the development and research of similar prescriptions.
