Animal model analysis of secretory otitis media based on characteristics of clinical symptoms of traditional Chinese and Western medicine.
10.19540/j.cnki.cjcmm.20201113.601
- Author:
Ya-Nan ZHANG
1
;
Ming BAI
1
;
Xiang-Xiang HUI
1
;
Sai WANG
1
;
Ming-San MIAO
1
Author Information
1. College of Pharmacy,Henan University of Chinese Medicine Zhengzhou 450046,China.
- Publication Type:Journal Article
- Keywords:
animal model;
clinical symptoms;
secretory otitis media
- MeSH:
Animals;
China;
Disease Models, Animal;
Medicine;
Medicine, Chinese Traditional;
Otitis Media with Effusion/drug therapy*
- From:
China Journal of Chinese Materia Medica
2021;46(4):767-771
- CountryChina
- Language:Chinese
-
Abstract:
Based on the characteristics of clinical symptoms of secretory otitis media in traditional Chinese and Western medicine,by reference to clinical diagnostic criteria,efforts were made to analyze and establish the Western medical diagnostic criteria and traditional Chinese medicine( TCM) syndrome differentiation criteria for secretory otitis media,and summarize the modeling methods and model characteristics of secretory otitis media animal models. According to the clinical diagnostic criteria and symptom characteristics,the coincidence degree between the existing animal models and clinical symptoms was evaluated,and its advantages and disadvantages were defined. On the basis of the statistical results,there were fewer methods for modeling secretory otitis media animal models,and only a specific relevant pathogenic mechanism could be revealed. Among them,the model with a higher coincidence degree was genetic engineering technology modeling and injection into the middle ear vesicles. The two modeling methods of bacterial factors highly coincided with the clinical symptoms of Western medicine,but both failed to reflect the TCM syndrome type. Therefore,establishing an animal model that simultaneously reflects the characteristics of clinical symptoms of secretory otitis media in traditional Chinese and Western medicine,and improving the evaluation criteria of secretory otitis media based on animal models are the main tasks of future studies on secretory otitis media.
