Systematic evaluation and sequential Meta-analysis of modified Xuefu Zhuyu Decoction combined with Western medicine in treatment of leiomyoma.
10.19540/j.cnki.cjcmm.20200401.501
- Author:
Lei ZENG
1
;
Shu-Liang JI
2
;
Hui-Qi CHEN
3
;
Song-Ping LUO
4
Author Information
1. Maternity and Child Center, the First Affiliated Hospital of Guangzhou University of Chinese Medcine, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine Guangzhou 510405, China.
2. the First Clinical College,Guangzhou University of Chinese Medcine Guangzhou 510405, China.
3. the Second Clinical College, Guangzhou University of Chinese Medcine Guangzhou 510405, China.
4. the First Affiliated Hospital of Guangzhou University of Chinese Medcine Guangzhou 510405, China.
- Publication Type:Meta-Analysis
- Keywords:
Meta-analysis;
leiomyoma;
mifepristone;
modified Xuefu Zhuyu Decoction;
sequential analysis;
therapeutic efficacy
- MeSH:
Drugs, Chinese Herbal;
Humans;
Leiomyoma/drug therapy*;
Medicine
- From:
China Journal of Chinese Materia Medica
2021;46(1):225-236
- CountryChina
- Language:Chinese
-
Abstract:
CNKI, PubMed and other databases were retrieved to extract eligible randomized controlled trial(RCT) about modified Xuefu Zhuyu Decoction(MXZD) combined with Western medicine(trial group) versus Western medicine alone(control group) in the treatment of leiomyoma. Therefore, a total of 25 RCTs were included, involving 2 328 patients. Bias risk evaluation tool in Cochrane Handbook 5.1.0 was used for evaluating the quality of these RCTs. Meta-analysis was performed for the reported indicators, including total efficiency, serum hormone level [progesterone(P), luteinizing hormone(LH), estradiol(E_2), follicle stimulating hormone(FSH)], uterine size, fibroids size and adverse reactions by using Stata 14.0 software. Meta-analysis showed that the total efficiency(RR=1.21,95%CI[1.17,1.25],P<0.05) of trial group was better than that of control group. Serum hormone level(WMD_P=-3.86,95%CI[-4.31,-3.41],P<0.05; WMD_(LH)=-3.64,95%CI[-4.47,-2.82],P<0.05; WMD_(E_2)=-39.99,95%CI[-53.45,-26.52],P<0.05; WMD_(FSH)=-3.79,95%CI[-4.86,-2.72],P<0.05), uterine size(WMD=-50.02,95%CI[-55.98,-44.06],P<0.05), fibroids size(WMD=-15.79,95%CI[-18.11,-13.46],P<0.05) and adverse reactions(RR=0.65,95%CI[0.48,0.88],P<0.05) of trial group were all lower than those of control group, with statistical significances. Trial sequential analysis(TSA) was performed by using TSA 0.9 software, and showed a reliable therapeutic effect of the experimental group. In short, our study indicated that modified Xuefu Zhuyu Decoction combined with Western medicine had a better therapeutic effect on leiomyoma than Western medicine alone, but more high-quality studies are needed to verify this conclusion in the future.
