A novel flavanone from Thymus przewalskii.
10.19540/j.cnki.cjcmm.20200628.202
- Author:
Xiao-Qiang CHANG
1
;
Yue MA
1
;
Peng SUN
1
;
Peng GAO
1
;
Yi-Fan ZHAO
1
;
Li-Wei GU
1
;
Dong ZHANG
1
;
Lan YANG
1
;
Ji-Xiang TIAN
2
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China Artemisinin Research Center, China Academy of Chinese Medical Sciences Beijing 100700, China.
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Thymus przewalskii;
chemical constituents;
cytotoxicity;
flavanone
- MeSH:
Chromatography, High Pressure Liquid;
Flavanones;
Humans
- From:
China Journal of Chinese Materia Medica
2021;46(1):125-129
- CountryChina
- Language:Chinese
-
Abstract:
This study was to investigate the chemical constituents from the aerial parts of Thymus przewalskii. The chemical consti-tuents were separated and purified by column chromatography on silica gel, ODS, Sephadex LH-20 and semi-prepared HPLC, and their structures were determined by physicochemical properties and spectroscopic data. Four flavanones were isolated from the ethanol extract of the aerial parts of T. przewalskii, and identified as(2S)-5,6-dihydroxy-7,8,4'-trimethoxyflavanone(1), 5,4'-dihydroxy-6,7-dimethoxyflavanone(2),(2S)-5,4'-dihydroxy-7,8-dimethoxyflavanone(3), sakuranetin(4), respectively. Compound 1 was a new compound and its configuration was determined by CD spectrum, compound 3 was natural product which was isolated for the first time and their configurations were determined by CD spectra. Compound 2 was isolated from the genus Thymus for the first time and compound 4 was isolated from T. przewalskii for the first time. Furthermore, cytotoxicity test was assayed for the four flavanones. They exhibited weak cytotoxicity against human lung cancer cells(A549), with the IC_(50) from 74.5 to 135.6 μmol·L~(-1).
