Research progress of effect of berberine in treatment of ulcerative colitis based on cell signaling pathway.
10.19540/j.cnki.cjcmm.20201002.601
- Author:
Jia-Jun WANG
1
;
Jian WANG
1
;
Yong LI
1
;
Mi-Hong REN
1
;
Yin FU
1
;
Xian-Juan YANG
1
;
Li-Ying WANG
1
Author Information
1. College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
- Publication Type:Journal Article
- Keywords:
berberine;
cell signaling pathway;
intestinal barrier mechanism;
ulcerative colitis
- MeSH:
Berberine/pharmacology*;
Colitis;
Colitis, Ulcerative/genetics*;
Humans;
Intestinal Mucosa;
Signal Transduction
- From:
China Journal of Chinese Materia Medica
2021;46(1):33-40
- CountryChina
- Language:Chinese
-
Abstract:
Berberine is the main extract of Coptis chinensis, and its anti-inflammatory, antioxidant, antibacterial and immunomodulatory effects have been confirmed by modern studies. Ulcerative colitis(UC) is a chronic, idiopathic inflammatory bowel disease with unknown etiology. Its causes involve genetics, intestinal microecology and mucosal immune system disorders. In this paper, literatures on relevant pathways and mechanism of berberine on ulcerative colitis in recent years were consulted and summarized to provide me-thods and ideas for developing berberine in the treatment of UC and exploring the mechanisms. The results showed that berberine protects the intestinal mucosal barrier, restores the body's normal immune response, and improves oxidative stress by regulating multiple signaling pathways, such as JAK-STAT, NK-κB, PI3 K-AKT, MAPK, Nrf2, ERS, and MLCK-MLC, so as to treat UC.
