New effect of G-protein coupled receptors on blood pressure regulation.
10.19540/j.cnki.cjcmm.20200930.601
- Author:
Hong-Xia DU
1
;
Guang-Xu XIAO
1
;
Xiao-Li DU
2
;
Yan ZHU
1
Author Information
1. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Research Institute Tianjin 300457, China.
2. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Research Institute Tianjin 300457, China Inner Mongolia Medical University Hohhot 010110, China.
- Publication Type:Journal Article
- Keywords:
GPCRs;
GPR41;
OLFR78;
blood pressure regulation;
gut microbiota;
hypertension
- MeSH:
Blood Pressure;
GTP-Binding Proteins;
Gastrointestinal Microbiome;
Humans;
Hypertension/genetics*;
Receptors, G-Protein-Coupled/metabolism*
- From:
China Journal of Chinese Materia Medica
2021;46(1):6-14
- CountryChina
- Language:Chinese
-
Abstract:
Hypertension is a clinical syndrome characterized by elevated systemic arterial blood pressure, which may be accompanied by functional or organic damage of heart, brain, kidney and other organs. The pathogenesis and development of hypertension are affected by genetic, environmental, epigenetic, intestinal microbiota and other factors. They are the result of multiple factors that promote the change of blood pressure level and vascular resistance. G protein coupled receptors(GPCRs) are the largest and most diverse superfamily of transmembrane receptors that transmit signals across cell membranes and mediate a large number of cellular responses required by human physiology. A variety of GPCRs are involved in the control of blood pressure and the maintenance of normal function of cardiovascular system. Hypertension contributes to the damages of heart, brain, kidney, intestine and other organs. Many GPCRs are expressed in various organs to regulate blood pressure. Although many GPCRs have been used as therapeutic targets for hypertension, their efficacy has not been fully studied. The purpose of this paper is to elucidate the role of GPCRs in blood pressure regulation and its distribution in target organs. The relationship between GPCRs related to intestinal microorganisms and blood pressure is emphasized. It is proposed that traditional Chinese medicine may be a new way to treat hypertension by regulating the related GPCRs via intestinal microbial metabolites.
