Effect of neutrophil extracellular traps on ischemic stroke and intervention of traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20200908.601
- Author:
Ming-Zhu QI
1
;
Xiao-Hui SU
1
;
Na LIN
1
;
Xiang-Ying KONG
1
Author Information
1. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Review
- Keywords:
ischemic stroke;
neutrophil extracellular traps;
platelet;
thrombo-inflammation
- MeSH:
Adult;
Brain Ischemia/drug therapy*;
China;
Extracellular Traps;
Humans;
Ischemic Stroke;
Medicine, Chinese Traditional;
Stroke/drug therapy*
- From:
China Journal of Chinese Materia Medica
2021;46(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is the leading cause of death and disability in adults in China. Recent studies have shown that neutrophil extracellular traps play a crucial role in occurrence and development of ischemic stroke. This paper reviewed the literatures on NETs since the discovery of NETs more than a decade ago, and summarized the composition of NETs, the effects of NETs on stroke, the intervention targets of NETs, and the effects of traditional Chinese medicine on NETs. NETs are an important cause of brain injury after stroke. Platelets, peptidylarginine deiminase 4, reactive oxygen species and histones are the targets to regulate NET formation in stroke. There are few researches on traditional Chinese medicine targeting NETs for stroke. Studies on the intervention of traditional Chinese medicine mainly target on neutrophils, which are the main components of NETs, and platelets, which induce the formation of NETs. The paper provided a comprehensive overview of current studies of NETs in ischemic stroke, so as to provide new ideas for the treatment and drug development of ischemic stroke.
