A new quinoline alkaloid from Scolopendra subspinipes mutilans.

Author: Yong-Xia GUAN ¹ ; Yan-Fang LI ¹ ; Jian-Wei FAN ¹ ; Wei-Qun LI ¹ ; Cheng-Shuai YU ¹ ; Qing-Feng LIU ¹ ; Hui-Fang ZHUANG ¹ ; Gui-Min ZHANG ¹
Author Information

1. State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Hope Pharmaceutical Co., Ltd. Linyi 276006, China.
Publication Type:Journal Article
Keywords: Scolopendra subspinipes mutilans(centipede); quinoline alkaloid; scolosprine C
MeSH: Alkaloids; Animals; Arthropods; Chilopoda; Quinolines
From: China Journal of Chinese Materia Medica 2021;46(3):635-637
CountryChina
Language:Chinese
Abstract: Three compounds, including scolosprine C(1), uracil(2) and hypoxanthine(3), were isolated and purified from the ethyl acetate fraction of centipede by silica gel normal-phase column chromatography, reversed-phase medium pressure preparation chromatography, and high-pressure semi-preparative HPLC. The structure was elucidated through a combination of spectroscopic analyses [such as nuclear magnetic resonance(NMR) and mass spectrometry(MS)] and literature review. Among them, compound 1 was a new quinoline alkaloid. In previous reports, we have described the isolation and structure elucidation of one new and two known quinoline alkaloids. In this paper, we would report the isolation and structure elucidation of scolosprine C in detail.