Research progress and analysis on mechanism of polysaccharides against type 2 diabetes mellitus.
10.19540/j.cnki.cjcmm.20201125.601
- Author:
Fu-Jun LIU
1
;
Xiao-Ying LIU
1
;
Yu MA
1
;
Wei-Lan WANG
1
;
Jin-Yao LI
1
Author Information
1. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology,Xinjiang University Urumqi 830046, China.
- Publication Type:Journal Article
- Keywords:
gut microbiota;
intracellular signaling pathway;
polysaccharides;
polysaccharides modification;
type 2 diabetes mellitus
- MeSH:
Blood Glucose;
Diabetes Mellitus, Type 2/drug therapy*;
Humans;
Hypoglycemic Agents/pharmacology*;
Insulin Resistance;
Polysaccharides
- From:
China Journal of Chinese Materia Medica
2021;46(3):552-559
- CountryChina
- Language:Chinese
-
Abstract:
Polysaccharides are macromolecular compounds formed by more than 10 monosaccharide molecules linked by glycosidic bonds. Polysaccharides have a wide range of sources, high safety and low toxicity, with a variety of biological activities, such as anti-tumor, anti-virus, immune regulation, lowering blood glucose, and lowering blood lipids. Type 2 diabetes mellitus(T2 DM) is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance and low inflammation. In recent years, the treatment of T2 DM with polysaccharide has become a research hotspot. Polysaccharides can not only make up for the side effects such as hypoglycemia, weight gain, gastrointestinal injury caused by long-term treatment of acarbose, biguanidine and sulfonylurea, but also play an effective role in reducing glucose by regulating glucose metabolism, oxidative stress, inflammatory response, intestinal flora, etc. In this paper, the research progress of polysaccharides in the treatment of T2 DM was reviewed. In addition, the hot spots such as the hypoglycemic activity of polysaccharides with structural modifications were summarized, providing theoretical guidance for the development of active polysaccharide hypoglycemic medicines and the further study of action mechanism.
