Design and application of quality standard of Dao-di herbs.
10.19540/j.cnki.cjcmm.202027.601
- Author:
Chang-Jiang-Sheng LAI
1
;
Xu-Ya WEI
1
;
Zi-Dong QIU
1
;
Ting TAN
2
Author Information
1. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
2. National Pharmaceutical Engineering Center (NPEC) for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine Nanchang 330006, China.
- Publication Type:Journal Article
- Keywords:
Dao-di herbs;
geoherbalism;
international standard;
quality marker;
quality standard;
rapid detection technology
- MeSH:
Drugs, Chinese Herbal;
Medicine, Chinese Traditional;
Plants, Medicinal;
Reference Standards;
Technology
- From:
China Journal of Chinese Materia Medica
2020;45(24):6072-6080
- CountryChina
- Language:Chinese
-
Abstract:
Dao-di herbs, which are widely recognized as medicinal materials with a high quality and good efficacy in clinic, are now facing the dilemma of absence of standard. This study focused on a pivotal scientific problem of design and application of quality standard of Dao-di herbs, and systematically illustrated the general rules for the quality standard of Dao-di herbs involving "four rules, six core contents, and three key methods". The quality standard of Dao-di herbs shall be fully based on literatures as well as habitat, planting/breeding, processing, characters, chemical-pharmacological/toxic data. The common requirements for the quality standard of Dao-di herbs contain "clear source, explicit origin, rational indicator, gradable quality, and multiple detection methods". Notably, traditional experiences and modern techniques, quality tracing management system, "quality determination by distinguishing characters" method, rapid detection technology, effective/toxic substances control method, were comprehensively applied in this standard to purse the objectification, automation, and intellectualization of detection technology. Appearance characters, chemical components, and bioactive parameters, unified effective/toxic indicators, quality markers, and pharmacopeial control indicators and reasonable ranges were included in rigorous quality standards for Dao-di herbs. Besides, simple grading method shall be developed to guide the implementation of "high quality-high price" policy. Eventually, the new quality standards for Dao-di herbs will lead international standards and promote the high-quality development of Dao-di herbs.
