Research progress of natural non-alkaloids with analgesic activity.
10.19540/j.cnki.cjcmm.20201104.201
- Author:
Ling-Yan WANG
1
;
Huan XIA
2
;
Gui-Yang XIA
2
;
Xiao-Hong WEI
2
;
Gui-Hua TIAN
2
;
Sheng LIN
3
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050,China.
2. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700,China.
3. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700,China State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050,China.
- Publication Type:Journal Article
- Keywords:
analgesic;
coumarins;
flavonoids;
natural products;
non-alkaloids;
pain;
terpenes
- MeSH:
Analgesics/therapeutic use*;
Analgesics, Opioid/therapeutic use*;
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use*;
Biological Products/therapeutic use*;
Humans;
Pain/drug therapy*
- From:
China Journal of Chinese Materia Medica
2020;45(24):5840-5865
- CountryChina
- Language:Chinese
-
Abstract:
Pain is a complex, unpleasant feeling and emotional experience associated with actual or potential tissue damage, and manifests itself in certain autonomous psychological and behavioral responses. The commonly used opioid and non-steroidal anti-inflammatory analgesics(NSAIDs) may cause adverse reactions to the kidney, liver, cardiovascular or gastrointestinal system and cause problems of drug abuse. Therefore, it is necessary to study new analgesic drugs with less side effects and significant analgesic effects. A variety of natural products derived from terrestrial plants, microorganisms, marine organisms and fungi have been an important source of clinical medicines and provide an inexhaustible resource for the development and innovation of modern medicines. Therefore, this paper mainly reviews the natural non-alkaloids with analgesic activity in order to provide reference for the research and development of analgesic drugs derived from natural products.
