Multi-targeted therapeutic effects of Huangkui Capsules on insulin resistance and urine microalbumin in early diabetic kidney disease patients.
10.19540/j.cnki.cjcmm.20200925.501
- Author:
Wei WU
1
;
Ying-Lu LIU
1
;
Yi-Gang WAN
1
;
Dong-Wei CAO
2
;
Qi-Jun FANG
3
;
Yue TU
4
;
Bu-Hui LIU
5
;
Wen-Wen WANG
3
;
Mei-Zi WANG
3
;
Hong-Yun YEE
3
;
Can-Can YUAN
3
;
Wei HU
6
Author Information
1. Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
2. Department of Nephrology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
3. Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Chinese Medicine and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210008, China.
4. Department of Traditional Chinese Medicine Health Preservation, Acupuncture and Moxibustion and Massage College·Health Preservation and Rehabilitation College, Nanjing University of Chinese Medicine Nanjing 210023, China.
5. Nephrology Division, Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029, China.
6. Department of Pharmacy, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
- Publication Type:Journal Article
- Keywords:
Huangkui Capsules;
diabetic kidney disease;
insulin resistance;
urine microalbumin
- MeSH:
Albuminuria;
Capsules;
Diabetes Mellitus;
Diabetic Nephropathies;
Drugs, Chinese Herbal;
Humans;
Insulin;
Insulin Resistance;
Kidney;
Retrospective Studies
- From:
China Journal of Chinese Materia Medica
2020;45(23):5797-5803
- CountryChina
- Language:Chinese
-
Abstract:
To observe the multi-targeted therapeutic effects of Huangkui Capsules(HKC)on insulin resistance(IR)and urine microalbumin in the early diabetic kidney disease(DKD)patients. The case data from the 83 DKD patients at G2 and A2 stage were collected respectively and analyzed retrospectively. According to the different treatment,all patients were divided into the control(A)group(40 cases)and the treated(B)group(43 cases). Among them,the A group patients were received "routine basic treatment";the B group patients were received "routine basic treatment+HKC". For the 2 group patients,firstly,the baseline parameters before receiving the treatment were compared respectively,and then,the changes of the total scores of traditional Chinese medicine(TCM) syndromes and the indicators of IR,urine protein,renal function,blood lipids and safety after receiving the treatment for 8 weeks were compared,respectively. Furthermore,for the all patients,the correlation analysis between IR and urine protein or IR and the total scores of TCM syndromes was carried out,respectively. The results showed that,for the B group patients received "routine basic treatment",their total scores of TCM syndromes,urine protein indicators including urine microalbumin(micro-UAlb) and urine microalbumin/urinary creatinine(UACR),IR indicators including fasting serum insulin(FIN)and homeostasis model assessment of insulin resistance(HOMA-IR)were significantly improved,respectively. For the all DKD patients,before and after the treatment,the main IR indicators(FIN and HOMA-IR)were positively correlated with urine protein indicators(micro-UAlb and UACR). The main IR indicators(FIN and HOMA-IR) were also positively correlated with the total scores of TCM syndromes. In addition,2 treatments had no significant effects on renal function,blood lipids and safety indicators in the all DKD patients. Overall, "routine basic treatment+HKC" can ameliorate IR and reduce urine microalbumin in the early DKD patients. Its therapeutic targets may be not only proteinuria,but also IR,which is the upstream risk factor of proteinuria.
