Anti-arthritic-related metal bioavailability for optimal compatibility ratio of Aconiti Radix Cocta and Paeoniae Radix Alba.
10.19540/j.cnki.cjcmm.20200904.202
- Author:
Lu-Xiu LIN
1
;
Feng-Ying ZHENG
1
;
Gui-Zhen HUANG
2
;
Shun-Xing LI
1
;
Feng-Jiao LIU
3
;
Shan MAN
4
;
Ji-Ru WU
4
;
Ying-Ying LI
4
Author Information
1. Fujian Provincial Key Laboratory of Pollution Monitoring and Control, Minnan Normal University Zhangzhou 363000, China Fujian Provincial Key Laboratory of Modern Analytical Science and Separation Technology, Minnan Normal University Zhangzhou 363000, China College of Chemistry, Chemical Engineering and Environment, Minnan Normal University Zhangzhou 363000, China.
2. MinXi Vocational & Technical College Longyan 364021, China.
3. Fujian Provincial Key Laboratory of Pollution Monitoring and Control, Minnan Normal University Zhangzhou 363000, China College of Chemistry, Chemical Engineering and Environment, Minnan Normal University Zhangzhou 363000, China.
4. College of Chemistry, Chemical Engineering and Environment, Minnan Normal University Zhangzhou 363000, China.
- Publication Type:Journal Article
- Keywords:
Aconiti Radix Cocta;
Paeoniae Radix Alba;
anti-arthritic-related metal;
bioavailability;
herbal plants compatibility;
in vitro bionic model;
rheumatoid arthritis
- MeSH:
Aconitum;
Biological Availability;
Drugs, Chinese Herbal;
Paeonia
- From:
China Journal of Chinese Materia Medica
2020;45(23):5770-5776
- CountryChina
- Language:Chinese
-
Abstract:
Trace metals deficiency or excess are associated with the etiology and pathogenesis of rheumatoid arthritis(RA). Aconiti Radix Cocta(A) and Paeoniae Radix Alba(B) are commonly used together for the treatment of RA. In this study, we aim to determine anti-arthritic-related metal bioavailability in the compatibility of herb A and B for avoiding metal deficiency or excess, and optimize the combination ratio of herb A and B, accordingly. Anti-arthritic-related metal bioaccessibility were evaluated by in vitro simulator of all gastrointestinal tract(including mouth, stomach, small and large intestines), and the roles of gastrointestinal digestive enzymes and intestinal microflora were investigated. Anti-arthritic-related metal bioavailability was assessed by the affinity adsorption with liposomes. The results indicated that compatibility proportion of corresponding herbal plants, gastrointestinal digestion and microbial metabolic, which could affect metal digestion and absorption. The optimal compatibility proportion of 1 A∶1 B is recommended, according to the dose of anti-arthritic-related metal bioavailability, which is often chosen for clinical practice of RA therapy. Thus, anti-arthritic-related metal bioavailability might be the key active substances for RA treatment.
