Molecular genetics of medicinal plants, past achievement, and new era.
10.19540/j.cnki.cjcmm.20201016.601
- Author:
Shi-Lin CHEN
1
;
Wei SUN
1
;
Wen-Guang WU
1
;
Wan-Sheng CHEN
2
;
Ying WANG
3
;
Yang DONG
4
;
Yi-Fei LIU
5
;
Zhi-Chao XU
6
;
Chao SUN
6
;
Qing-Gang YIN
1
;
Yong-Qing LI
3
;
Ming LUO
3
;
Ying XIAO
7
;
Hui-Hua WAN
1
Author Information
1. Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
2. Department of Pharmacy,Changzheng Hospital,Second Military Medical University Shanghai 200003,China Research and Development Center of Chinese Medicine Resources and Biotechnology,Shanghai University of Traditional Chinese Medicine Shanghai 201203,China.
3. Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement,South China Botanical Garden,Chinese Academy of Sciences Guangzhou 510650,China.
4. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,Yunnan Agricultural University Kunming 650201,China Yunnan Research Institute for Local Plateau Agriculture and Industry Kunming 650201,China.
5. College of Pharmacy,Hubei University of Chinese Medicine Wuhan 430065.
6. Institute of Medicinal Plant Development,Chinese Academy of Medical Science & Peking Union Medical College Beijing 100193,China.
7. Research and Development Center of Chinese Medicine Resources and Biotechnology,Shanghai University of Traditional Chinese Medicine Shanghai 201203,China.
- Publication Type:Journal Article
- Keywords:
enzyme;
molecular genetics of medicinal plants;
omics;
population genetics;
transcription regulation
- MeSH:
Biosynthetic Pathways;
Genomics;
Molecular Biology;
Plant Breeding;
Plants, Medicinal
- From:
China Journal of Chinese Materia Medica
2020;45(23):5577-5588
- CountryChina
- Language:Chinese
-
Abstract:
Unraveling the genetic basis of medicinal plant metabolism and developmental traits is a long-standing goal for pharmacologists and plant biologists. This paper discusses the definition of molecular genetics of medicinal plants, which is an integrative discipline with medicinal plants as the research object. This discipline focuses on the heredity and variation of medicinal plants, and elucidates the relationship between the key traits of medicinal plants(active compounds, yield, resistance, etc.) and genotype, studies the structure and function, heredity and variation of medicinal plant genes mainly at molecular level, so as to reveal the molecular mechanisms of transmission, expression and regulation of genetic information of medicinal plants. Specifically, we emphasize on three major aspects of this discipline.(1)Individual and population genetics of medicinal plants, this part mainly highlights the genetic mechanism of the domestication, the individual genomics at the species level, and the formation of genetic diversity of medicinal plants.(2)Elucidation of biosynthetic pathways of active compounds and their evolutionary significance. This part summarizes the biosynthesis, diversity and molecular evolution of active compounds in medicinal plants.(3) Molecular mechanisms that shaping the key agronomic traits by internal and external factors. This part focuses on the accumulation and distribution of active compounds within plants and the regulation of metabolic network by environmental factors. Finally, we prospect the future direction of molecular genetics of medicinal plants based on the rapid development of multi-omics technology, as well as the application of molecular genetics in the future strategies to achieve conservation and breeding of medicinal plants and efficient biosynthesis of active compounds.
