Advances in studies on steroidal alkaloids and their pharmacological activities in genus Veratrum.
10.19540/j.cnki.cjcmm.20200612.201
- Author:
Meng-Zhen ZHANG
1
;
Li-Juan GAO
1
;
Xu SHI-FANG
1
;
Wen-Kang HUANG
1
;
Li XIAO-YU
1
;
Ye YI-PING
1
Author Information
1. Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica,Hangzhou Medical College Hangzhou 310013, China.
- Publication Type:Journal Article
- Keywords:
chemical constituents;
genus Veratrum;
pharmalogical activities;
steroidal alkaloids
- MeSH:
Alkaloids/pharmacology*;
Analgesics;
Platelet Aggregation;
Steroids/pharmacology*;
Veratrum
- From:
China Journal of Chinese Materia Medica
2020;45(21):5129-5142
- CountryChina
- Language:Chinese
-
Abstract:
Genus Veratrum plants contain a diversity of steroidal alkaloids, so far at least 184 steroidal alkaloids attributed to cevanine type(A-1～A-69), veratramine type(B-1～B-21), jervanine type(C-1～C-31), solanidine type(D-1～D-10) and verazine type(E-1～E-53), respectively, have been isolated and identified in the genus Veratrum. Their pharmacological activities mainly focused on decreasing blood pressure, anti-platelet aggregation and anti-thrombosis, anti-inflammatory and analgesic, and antitumor effect. This paper classified and summarized the 184 kind of steroidal alkaloids from the Veratrum plants and their major pharmalogical activities in order to provide the scientific basis for the further development and utilization of active alkaloids.
