Research progress of ion channels relating to cerebral ischemic diseases and prevention and treatment with traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20200709.602
- Author:
Jia-Le GAO
1
;
Jian-Xun LIU
1
Author Information
1. Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
ion channels;
research progress;
traditional Chinese medicine
- MeSH:
Brain Ischemia/drug therapy*;
Humans;
Ischemia;
Medicine, Chinese Traditional;
Neurons;
Quality of Life
- From:
China Journal of Chinese Materia Medica
2020;45(21):5110-5116
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia is a series of clinical symptoms and signs of cerebral ischemia, hypoxia and neuronal damage caused by cerebral artery stenosis or occlusion due to atherosclerosis or thrombosis, which seriously affects human health and quality of life. Cerebral ischemia involves the cascade reaction of the "neurovascular unit" system, and finally affects the normal physiological function of nerve cells and produces a series of pathological changes. And the changes in the structure and function of various ion channels in the cell membrane play an important role during this process. This article illustrates the changes in the ion channel associated with ce-rebral ischemic diseases, such as the potassium ion channels, sodium ion channels, calcium channels and other relevant channels, like AQP, TRPM2, TRPM7, TRPV4, ASICs, Cl~- channel, and explores the intervention effect of traditional Chinese medicine in prevention and treatment of cerebral ischemic diseases from the perspective of ion channels, in order to provide references for potential targets involving in drug development for the future prevention and treatment of cerebral ischemic diseases.
