Research Advances of Human Homologue of Mouse Progressive Ankylosis Protein and Bone and Joint Diseases.
10.3881/j.issn.1000-503X.12795
- Author:
Peng YU
1
;
Xi Sheng WENG
2
Author Information
1. Department of International Medical Service,CAMS and PUMC,Beijing 100730,China.
2. Department of Orthopaedics,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Review
- Keywords:
articular cartilage calcification;
calcium pyrophosphate deposition;
craniometaphyseal dysplasia;
human homologue of mouse progressive ankylosis protein
- MeSH:
Ankylosis;
Humans;
Hyperostosis;
Hypertelorism;
Joint Diseases;
Mice;
Mutation
- From:
Acta Academiae Medicinae Sinicae
2021;43(2):293-299
- CountryChina
- Language:Chinese
-
Abstract:
The human homologue of mouse progressive ankylosis protein(ANKH)is an inorganic pyrophosphate transport regulator,which regulates tissue mineralization by controlling the level of inorganic pyrophosphate.It plays an important role in the pathogenesis and development of bone and joint diseases,such as ankylosing spondylitis,craniometaphyseal dysplasia,and articular cartilage calcification.This review summarizes the progress of research on ANKH and the above-mentioned diseases.
