Research Progress on Role and Mechanism of Elabela in Organ Fibrosis.
10.3881/j.issn.1000-503X.13014
- Author:
Yu ZHANG
1
;
Pei Ting LUO
1
;
Xin Yang LI
1
;
Wen Peng CUI
1
Author Information
1. Department of Nephrology,The Second Hospital of Jilin University,Changchun 130041,China.
- Publication Type:Review
- Keywords:
Apelin receptor;
Elabela;
fibrosis
- MeSH:
Apelin;
Apelin Receptors;
Blood Pressure;
Female;
Fibrosis;
Humans;
Peptide Hormones;
Pregnancy
- From:
Acta Academiae Medicinae Sinicae
2021;43(2):278-282
- CountryChina
- Language:Chinese
-
Abstract:
Elabela is a newly discovered peptide in recent years.It is the endogenous ligand of Apelin receptor(APJ)and plays an important role in embryonic development and adult organs.Elabela-APJ axis is closely related to organ fibrosis.Elabela can protect the functions of heart and kidney by antagonizing renin-angiotensin system and regulating blood pressure.In addition,it can prevent kidney and heart fibrosis by down-regulating the expression of fibrosis and inflammatory factors.However,there is a positive correlation between the level of Elabela and the degree of liver fibrosis,suggesting that Elabela may play a role in promoting liver fibrosis.This review aims to explore the role of Elabela-APJ axis in renal fibrosis,cardiac fibrosis,and liver fibrosis,and to provide a new therapeutic target for organ fibrosis.
