Application of Methylprednisolone Sodium Succinate Combined with Tropisetron in Prevention of Nausea and Vomiting under Microvascular Decompression of Hemifacial Spasm.
10.3881/j.issn.1000-503X.13399
- Author:
Dong Liang WANG
1
;
Hai Dong SONG
1
;
Qing Pei HAO
1
;
Ji Xia FANG
1
;
Bo LIU
1
;
Jing Ru ZHOU
1
;
Feng JIAO
1
;
Cun Gang FAN
1
;
Ru'en LIU
1
Author Information
1. Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China.
- Publication Type:Randomized Controlled Trial
- Keywords:
hemifacial spasm;
methylprednisolone sodium succinate;
microvascular decompression;
postoperative nausea and vomiting;
tropisetron
- MeSH:
Antiemetics;
Double-Blind Method;
Hemifacial Spasm/surgery*;
Humans;
Indoles;
Methylprednisolone Hemisuccinate/therapeutic use*;
Microvascular Decompression Surgery;
Tropisetron
- From:
Acta Academiae Medicinae Sinicae
2021;43(1):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of methylprednisolone sodium succinate combined with tropisetron on postoperative nausea and vomiting(PONV)under microvascular decompression of hemifacial spasm.Methods From January to June 2019,485 patients undergoing microvascular decompression for facial spasm at Department of Neurosurgery,Peking University People's Hospital were randomly assigned into two groups with random number table method.For group A(n=242),2 ml saline was administrated by intravenous drip before induction and 5 mg tropisetron after operation.For group B(n=243),40 mg methylprednisolone sodium succinate was administrated by intravenous drip before induction and 5 mg tropisetron after operation.The anesthesia time,operation time,and incidence of PONV in 0-24 h and 24-48 h were recorded for the comparison of the remedial treatment rate of nausea and vomiting between the two groups.Results There was no significant difference in age,gender,smoking history,body mass index value,American Society of Anesthesiologists score,medical history,surgical side,PONV history,operation time or anesthesia time between the two groups(all P > 0.05).The incidence of PONV in group A was 35.5% and 18.2% during 0-24 h and 24-48 h,respectively,which was significantly higher than that(18.5%,χ
