Toll-like Receptor Agonists in Radiation Protection.
10.3881/j.issn.1000-503X.12119
- Author:
Jiao GUO
1
;
Hai Yu YANG
1
;
Wei LONG
1
Author Information
1. Department of Pharmaceutica,Institute of Radiation Medicine,CAMS and PUMC,Tianjin 300192,China.
- Publication Type:Journal Article
- Keywords:
Toll-like receptor agonist;
nuclear factor-κB;
radiation protection
- MeSH:
Apoptosis;
Humans;
NF-kappa B;
Radiation Protection;
Radiation, Ionizing;
Radiation-Protective Agents/pharmacology*;
Toll-Like Receptors/agonists*
- From:
Acta Academiae Medicinae Sinicae
2020;42(6):805-809
- CountryChina
- Language:Chinese
-
Abstract:
Ionizing radiation causes the massive apoptosis of human tissue cells,leading to dysfunction of the gastrointestinal tract and hematopoietic system.Thus,high-efficiency,low-toxicity radiation protection drugs are urgently needed.Toll-like receptor agonists have been developed based on the anti-apoptotic mechanism of tumor cells in recent years,which exert their radioprotective effects by activating downstream pathways,mainly nuclear factor-κB.Here we elucidate several agonists of Toll-like receptors involved in radiation protection,with an attempt to inform the research and development of new radiation protection agents.
