Advances in metabolic engineering for the production of aromatic chemicals.

Author: Fengli WU ¹ ; Xiaoshuang WANG ¹ ; Fuqiang SONG ¹ ; Yanfeng PENG ¹ ; Qinhong WANG ¹
Author Information

1. CAS Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Publication Type:Review
Keywords: aromatic amino acid; aromatic chemicals; metabolic engineering; microbial fermentation; shikimate pathway
MeSH: Biosynthetic Pathways; Fermentation; Metabolic Engineering; Shikimic Acid
From: Chinese Journal of Biotechnology 2021;37(5):1771-1793
CountryChina
Language:Chinese
Abstract: Metabolic engineering has been developed for nearly 30 years since the early 1990s, and it has given a great impetus to microbial strain breeding and improvement. Aromatic chemicals are a variety of important chemicals that can be produced by microbial fermentation and are widely used in the pharmaceutical, food, feed, and material industry. Microbial cells can be engineered to accumulate a variety of useful aromatic chemicals in a targeted manner through rational engineering of the biosynthetic pathways of shikimate and the derived aromatic amino acids. This review summarizes the metabolic engineering strategies and biosynthetic pathways for the production of aromatic chemicals developed in the past 30 years, with the aim to provide a valuable reference and promote the research in this field.