Advances in the metabolic engineering for the production of tetracarbon organic acids.

Author: Yingshan WANG ¹ ; Feng GUO ¹ ; Wei YAN ¹ ; Fengxue XIN ¹ ; Wenming ZHANG ¹ ; Min JIANG ¹
Author Information

1. State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, Jiangsu, China.
Publication Type:Review
Keywords: C-4 organic acid; metabolic engineering; microbial fermentation; strain screening
MeSH: Acids; Biosynthetic Pathways; Fermentation; Metabolic Engineering; Organic Chemicals
From: Chinese Journal of Biotechnology 2021;37(5):1697-1720
CountryChina
Language:Chinese
Abstract: Tetracarbon organic acids are important platform chemicals that are widely used in the food, chemical, medicine, material industries and agriculture. Compared with the traditional petrochemical process, the production of tetracarbon organic acids by microbial fermentation is more promising due to milder reaction conditions, greener process and better environmental compatibility. This review summarizes the biosynthetic pathways and metabolic mechanisms for the production of tetracarbon organic acids, and illustrates recent advances, challenges, and future perspectives in the production of tetracarbon organic acids by naturally selected or purposefully engineered strains.