Advances in metabolic engineering of filamentous fungi.

Author: Jingen LI ¹ ; Qian LIU ¹ ; Defei LIU ¹ ; Min WU ¹ ; Chaoguang TIAN ¹
Author Information

1. Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Publication Type:Systematic Review
Keywords: bio-based products; filamentous fungi; metabolic engineering; systems biology
MeSH: Fungi/genetics*; Metabolic Engineering
From: Chinese Journal of Biotechnology 2021;37(5):1637-1658
CountryChina
Language:Chinese
Abstract: Filamentous fungi are important industrial microorganisms that play important roles in the production of bio-based products such as organic acids, proteins and secondary metabolites. The development of metabolic engineering and its enabling techniques have greatly promoted the design, construction and application of filamentous fungal cell factories. This article systematically reviews the development of filamentous fungal cell factories constructed through metabolic engineering, and discusses the challenges and future perspectives for systems metabolic engineering of filamentous fungi.