Metabolic regulation in constructing microbial cell factories.

Author: Yang LIU ¹ ; Qingxuan MU ¹ ; Ya'nan SHI ¹ ; Bo YU ¹
Author Information

1. CAS Key Laboratory of Microbial Physiological & Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Publication Type:Review
Keywords: metabolic engineering; microbial cell factories; regulation of gene expression; synthetic biology
MeSH: Metabolic Engineering; Metabolic Networks and Pathways/genetics*; Synthetic Biology
From: Chinese Journal of Biotechnology 2021;37(5):1541-1563
CountryChina
Language:Chinese
Abstract: The regulation of the expression of genes involved in metabolic pathways, termed as metabolic regulation, is vital to construct efficient microbial cell factories. With the continuous breakthroughs in synthetic biology, the mining and artificial design of high-quality regulatory elements have substantially improved our ability to modify and regulate cellular metabolic networks and its activities. The research on metabolic regulation has also evolved from the static regulation of single genes to the intelligent and precise dynamic regulation at the systems level. This review briefly summarizes the advances of metabolic regulation technologies in the past 30 years.