Thirty years development of metabolic engineering: a review.
- Author:
Tao CHEN
1
;
Zhenzhen CUI
1
;
Wenya HU
1
;
Zhiwen WANG
1
;
Xueming ZHAO
1
Author Information
- Publication Type:Review
- Keywords: bio-based products; metabolic engineering; microbial cell factories; synthetic biology; systems biology
- MeSH: Biotechnology; Industry; Metabolic Engineering; Synthetic Biology; Systems Biology
- From: Chinese Journal of Biotechnology 2021;37(5):1477-1493
- CountryChina
- Language:Chinese
- Abstract: Since its establishment 30 years ago, the discipline of metabolic engineering has developed rapidly based on its deep integration with molecular biology, systems biology and synthetic biology successively, which has greatly contributed to advancing and upgrading biotechnology industry. This review firstly analyzes the current status of academic research and China's competence in the area of metabolic engineering according to the data of papers published in SCI-indexed journals in the past 30 years. Subsequently, the article summarizes the development of systems biology methods and enabling technologies of synthetic biology and their applications in metabolic engineering in the past 10 years. Finally, the major challenges and future perspectives for the development of metabolic engineering are briefly discussed.
