Advances in the biosynthesis of natamycin and its regulatory mechanisms.

Author: Dahong WANG ¹ ; Wenhao SHEN ¹ ; Jiangfeng YUAN ¹ ; Jianrui SUN ¹ ; Mengyang WANG ¹
Author Information

1. College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, Henan, China.
Publication Type:Review
Keywords: biosynthesis; food preservative; natamycin; regulatory mechanism
MeSH: Antifungal Agents/pharmacology*; Fungi; Natamycin; Streptomyces
From: Chinese Journal of Biotechnology 2021;37(4):1107-1119
CountryChina
Language:Chinese
Abstract: Natamycin is a polyene macrolide antibiotics with strong and broad spectrum antifungal activity. It not only effectively inhibits the growth and reproduction of fungi, but also prevents the formation of some mycotoxins. Consequently, it has been approved for use as an antifungal food preservative in most countries, and is also widely used in agriculture and healthcare. Streptomyces natalensis and Streptomyces chatanoogensis are the main producers of natamycin. This review summarizes the biosynthesis and regulatory mechanism of natamycin, as well as the strategies for improving natamycin production. Moreover, the future perspectives on natamycin research are discussed.