Current status and future perspectives of metabolic network models of industrial microorganisms.

Author: Chenyang ZHANG ¹ ; Yaokang WU ¹ ; Xianhao XU ¹ ; Xueqin LV ¹ ; Jianghua LI ¹ ; Guocheng DU ¹ ; Long LIU ¹
Author Information

1. Science Center for Future Foods, Jiangnan University, Wuxi 214122, Jiangsu, China.
Publication Type:Journal Article
Keywords: genome-scale metabolic network model; model application; model construction; model evaluate indicators; typical industrial microorganisms
MeSH: Corynebacterium glutamicum/genetics*; Escherichia coli/genetics*; Metabolic Engineering; Metabolic Networks and Pathways/genetics*
From: Chinese Journal of Biotechnology 2021;37(3):860-873
CountryChina
Language:Chinese
Abstract: Genome-scale metabolic network model (GSMM) is an extremely important guiding tool in the targeted modification of industrial microbial strains, which helps researchers to quickly obtain industrial microbes with specific traits and has attracted increasing attention. Here we reviewe the development history of GSMM and summarized the construction method of GSMM. Furthermore, the development and application of GSMM in industrial microorganisms are elaborated by using four typical industrial microorganisms (Bacillus subtilis, Escherichia coli, Corynebacterium glutamicum, and Saccharomyces cerevisiae) as examples. In addition, prospects in the development trend of GSMM are proposed.