Engineering progress in microbial production of polyhydroxyalkanoates.

Kai Yuan; Weiqiang Zhou; Chao Peng; Tang Tang; Qi Wang; Weitao Tang; Tai AN; Bo Chen; Haijun Liu; Lida WU; Yi LI; Yi Tong

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Engineering progress in microbial production of polyhydroxyalkanoates.

Author: Kai YUAN ¹ ; Weiqiang ZHOU ¹ ; Chao PENG ¹ ; Tang TANG ¹ ; Qi WANG ¹ ; Weitao TANG ¹ ; Tai AN ¹ ; Bo CHEN ¹ ; Haijun LIU ² ; Lida WU ² ; Yi LI ² ; Yi TONG ²
Author Information

1. Nutrition and Health Research Institute, COFCO, Beijing 102209, China.
2. COFCO Biochemical Co., Ltd., Bengbu 233010, Anhui, China.
Publication Type:Journal Article
Keywords: economic carbon source; genetic engineering; high density fermentation; open fermentation; polyhydeoxyalkanoates
MeSH: Fermentation; Industry; Petroleum; Plastics; Polyhydroxyalkanoates
From: Chinese Journal of Biotechnology 2021;37(2):384-394
CountryChina
Language:Chinese
Abstract: Polyhydroxyalkanoates (PHAs) are polymers obtained by esterification of hydroxy fatty acid monomers. Due to similar mechanical characteristics of traditional petroleum-based plastics, 100% biodegradability and biocompatibility, PHAs are considered to be one of the most potential green materials. However, the application and promotion of PHAs as a green and environmentally friendly material are difficult because of the high production costs. This article focuses on the current methods to reduce production cost of PHAs effectively, such as cell morphology regulation, metabolic pathway construction, economic carbon source utilization and open fermentation technology development. Despite most research results are still limited in laboratory, the research methods and directions provide theoretical guidance for the industrial production of economic PHAs.