Correlation between gut microbiota and liver biochemical indicators in patients with chronic hepatitis B.

Zhifang Zhao; Song Qin; Li Wang; Lili LI; Youde Liu; Lixia Deng; Zhiqiang Zou

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Correlation between gut microbiota and liver biochemical indicators in patients with chronic hepatitis B.

Author: Zhifang ZHAO ¹ ; Song QIN ¹ ; Li WANG ² ; Lili LI ¹ ; Youde LIU ² ; Lixia DENG ² ; Zhiqiang ZOU ²
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1. Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, Shandong, China.
2. Yantai City Hospital for infectious Diseases, Yantai 264001, Shandong, China.
Publication Type:Journal Article
Keywords: 16S rRNA; chronic hepatitis B; gut microbiota; liver biochemical indicators
MeSH: Bacteroides; Eubacterium; Gastrointestinal Microbiome; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms
From: Chinese Journal of Biotechnology 2021;37(1):301-311
CountryChina
Language:Chinese
Abstract: Chronic hepatitis B (CHB) is a global epidemic disease caused by hepatitis B virus that can lead to hepatic failure, even liver cirrhosis and hepatocellular carcinoma. The occurrence and development of CHB are closely related to the changes in the gut microbiota communities. To explore the relationship between the structure of gut microbiota and liver biochemical indicators, 14 CHB patients (the CHB group) and 11 healthy people (the CN group) were randomly enrolled in this study. Our results demonstrate that CHB caused changes in the gut microbiota communities and biochemical indicators, such as alanine transaminase, total bilirubin and gamma glutamyl transferase. Furthermore, CHB induced imbalance of the gut microbiota. Prevotella, Blautia, Ruminococcus, Eubacterium eligens group, Bacteroides uniformis and Ruminococcus sp. 5_1_39BFAA were associated with the critical biochemical indicators and liver injury, suggesting a new approach to CHB treatment.