Herpesvirus and endoplasmic reticulum stress.
- Author:
Yuting LIU
1
;
Guoxin LI
1
;
Bin WANG
2
Author Information
- Publication Type:Journal Article
- Keywords: endoplasmic reticulum stress; herpesvirus; unfolded protein response
- MeSH: Endoplasmic Reticulum/metabolism*; Endoplasmic Reticulum Stress; Herpesviridae; Signal Transduction; Unfolded Protein Response
- From: Chinese Journal of Biotechnology 2021;37(1):67-77
- CountryChina
- Language:Chinese
- Abstract: Endoplasmic reticulum (ER) is an important organelle where folding and post-translational modification of secretory and transmembrane proteins take place. During virus infection, cellular or viral unfolded and misfolded proteins accumulate in the ER in an event called ER stress. To maintain the equilibrium homeostasis of the ER, signal-transduction pathways, known as unfolded protein response (UPR), are activated. The viruses in turn manipulate UPR to maintain an environment favorable for virus survival and replication. Herpesviruses are enveloped DNA viruses that produce over 70 viral proteins. Modification and maturation of large quantities of viral glycosylated envelope proteins during virus replication may induce ER stress, while ER stress play both positive and negative roles in virus infection. Here we summarize the research progress of crosstalk between herpesvirus infection and the virus-induced ER stress.
