Progress in human epidermal growth factor research.

Author: Meiyu WU ¹ ; Jinghua RUAN ¹ ; Boxiong ZHONG ¹
Author Information

1. Department of Special Economic Animal Science, College of Animal Science, Zhejiang University, Hangzhou 310029, Zhejiang, China.
Publication Type:Review
Keywords: human epidermal growth factor; mechanisms; tumor; ulcers; wound repair
MeSH: Cell Proliferation; Epidermal Growth Factor/genetics*; ErbB Receptors/genetics*; Humans; Skin; Wound Healing
From: Chinese Journal of Biotechnology 2020;36(12):2813-2823
CountryChina
Language:Chinese
Abstract: Human epidermal growth factor (hEGF) is a typical member of the growth factor family that activates epidermal growth factor receptors. It is synthesized and secreted by multiple tissues and organs of the human body, regulating the cell proliferation, differentiation and migration via binding to receptors and activating a series of signaling pathways. In recent years, the research on hEGF has been extended to its role in human physiology and pathology, especially in tissue regeneration and wound healing. This paper reviews the research progress of hEGF, briefly describes its gene and protein structure and characteristics, mechanisms and biological effects, with the emphasis on the roles and influences in the healing of gastrointestinal ulcers, skin wound repair and tumor pathology.