Expert consensus on microbiome sequencing and analysis.

Yunfeng Duan; Shengyue Wang; Yubao Chen; Ruifu Yang; Houkai LI; Huaiqiu Zhu; Yigang Tong; Wenbin WU; Yu FU; Songnian HU; Jun Wang; Yuhua Xin; Fangqing Zhao; Yiming Bao; Wen Zhang; Juan LI; Ming Zeng; Haitao Niu; Xin Zhou; Yan LI; Shenghui Cui; Jing Yuan; Junhua LI; Jiayi Wang; Donglai Liu; Ming NI; Qing Sun; Ye Deng; Baoli Zhu

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Expert consensus on microbiome sequencing and analysis.

Author: Yunfeng DUAN ¹ ; Shengyue WANG ² ; Yubao CHEN ³ ; Ruifu YANG ⁴ ; Houkai LI ⁵ ; Huaiqiu ZHU ⁶ ; Yigang TONG ⁷ ; Wenbin WU ¹ ; Yu FU ¹ ; Songnian HU ¹ ; Jun WANG ¹ ; Yuhua XIN ¹ ; Fangqing ZHAO ⁸ ; Yiming BAO ⁹ ; Wen ZHANG ¹⁰ ; Juan LI ¹⁰ ; Ming ZENG ¹¹ ; Haitao NIU ¹² ; Xin ZHOU ¹³ ; Yan LI ¹⁴ ; Shenghui CUI ¹⁵ ; Jing YUAN ¹⁶ ; Junhua LI ¹⁷ ; Jiayi WANG ¹⁴ ; Donglai LIU ¹⁸ ; Ming NI ¹⁹ ; Qing SUN ¹⁴ ; Ye DENG ²⁰ ; Baoli ZHU ¹
Author Information

1. Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
2. National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
3. Beijing Computing Center, Beijing 100094, China.
4. Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100012, China.
5. Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China.
6. Peking University, Beijing 100871, China.
7. Beijing University of Chemical Technology, Beijing 100029, China.
8. Beijing Institutes of Biological Sciences, Chinese Academy of Sciences, Beijing 100101, China.
9. Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
10. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
11. China Institute of Food and Drug Control-Vaccine Room, Beijing 102629, China.
12. Institute of Medical Laboratory Animals, Peking Union Medical College, Beijing 100021, China.
13. China Agricultural University, Beijing 100083, China.
14. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
15. Food and Cosmetic Inspection and Testing Center, China Institute of Food and Drug Control, Beijing 102629, China.
16. Capital Institute of Pediatrics, Beijing 100020, China.
17. Beijing Genomics Institute at Shenzhen, Shenzhen 518083, Guangdong, China.
18. Institute of Diagnostic Reagents, China Institute for Food and Drug Control, Beijing 102629, China.
19. Academy of Military Medicine, Chinese Academy of Military Sciences, Beijing 100850, China.
20. Research Center for Ecological Environment, Chinese Academy of Sciences, Beijing 100085, China.
Publication Type:Journal Article
Keywords: expert consensus; high-throughput gene sequencing; microbiome; microbiome project; national standards
MeSH: China; Consensus; Humans; Industry; Microbiota
From: Chinese Journal of Biotechnology 2020;36(12):2516-2524
CountryChina
Language:Chinese
Abstract: In the past ten years, the research and application of microbiome has continued to increase. The microbiome has gradually become the research focus in the fields of life science, environmental science, and medicine. Meanwhile, many countries and organizations around the world are launching their own microbiome projects and conducting a multi-faceted layout, striving to gain a strategic position in this promising field. In addition, whether it is scientific research or industrial applications, there has been a climax of research and a wave of investment and financing, accordingly, products and services related to the microbiome are constantly emerging. However, due to the rapid development of microbiome sequencing and analysis related technologies and methods, the research and application from various countries have not yet unified on the standards of technology, programs, and data. Domestic industry participants also have insufficient understanding of the microbiome. New methods, technologies, and theories have not yet been fully accepted and used. In addition, some of the existing standards and guidelines are too general with poor practicality. This not only causes obstacles in the integration of scientific research data and waste of resources, but also gives related companies unfair competition opportunity. More importantly, China still lacks national standards related to the microbiome, and the national microbiome project is still in the process of preparation. In this context, the experts and practitioners of the microbiome worked together and developed the consensus of experts. It can not only guide domestic scientific research and industrial institutions to regulate the production, learning and research of the microbiome, the application can also provide reference technical basis for the relevant national functional departments, protect the scale and standardized corporate company's interests, strengthen industry self-discipline, avoid unregulated enterprises from disrupting the market, and ultimately promote the benign development of microbiome-related industries.