Bacterial stress response, physiological metabolism and antimicrobial tolerance and the control strategies.

Lulu Huang; Yufeng GU; Cuirong WU; Junhong Huang; Guyue Cheng

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Bacterial stress response, physiological metabolism and antimicrobial tolerance and the control strategies.

Author: Lulu HUANG ¹ ; Yufeng GU ¹ ; Cuirong WU ¹ ; Junhong HUANG ¹ ; Guyue CHENG ¹
Author Information

1. MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Publication Type:Review
Keywords: amino acid metabolism; antimicrobial tolerance; glucose metabolism; stress responses
MeSH: Animals; Anti-Bacterial Agents/pharmacology*; Anti-Infective Agents; Bacteria/genetics*; Drug Resistance, Bacterial; Stress, Physiological
From: Chinese Journal of Biotechnology 2020;36(11):2287-2297
CountryChina
Language:Chinese
Abstract: Overuse of antibiotics in medical care and animal husbandry has led to the development of bacterial antimicrobial resistance, causing increasingly more health concern. In addition to genetic mutations and the formation of resistance, the various stresses bacteria encountered in the natural environment trigger their stress responses, which not only protect them from these stresses, but also change their tolerance to antimicrobials. The emergence of antimicrobial tolerance will inevitably affect the physiological metabolism of bacteria. However, bacteria can restore their sensitivity to drugs by regulating their own metabolism. This article reviews recent studies on the relationship between bacterial stress responses or the physiological metabolism and antimicrobial tolerance, intending to take more effective measures to control the occurrence and spread of antimicrobial resistance.