Amino acid exporters and metabolic modification of Corynebacterium glutamicum - a review.

Author: Xiaomei ZHANG ¹ ; Yujie GAO ¹ ; Ling YANG ¹ ; Yi YANG ¹ ; Ping ZHENG ² ; Jibin SUN ² ; Jinsong SHI ¹ ; Zhenghong XU ³
Author Information

1. School of Pharmaceutics Science, Jiangnan University, Wuxi 214122, Jiangsu, China.
2. Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
3. National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, Jiangsu, China.
Publication Type:Review
Keywords: Corynebacterium glutamicum; amino acid; efflux; exporter; metabolic modification
MeSH: Amino Acids; Corynebacterium glutamicum/genetics*; Metabolic Engineering
From: Chinese Journal of Biotechnology 2020;36(11):2250-2259
CountryChina
Language:Chinese
Abstract: Amino acids are important compounds with a wide range of applications in the food, medicine and chemical industries. Corynebacterium glutamicum is a powerful workhorse commonly used in industrial amino acid production, with the scale of more than one million tons. In addition to its efficient anabolism, the effective exporters also ensure the high amino acid production by C. glutamicum. In this review, the research progress of amino acid exporter of C. glutamicum is summarized, to provide the foundation for further improving amino acid production by C. glutamicum via metabolic engineering.