Synthetic biology for the synthesis of mogroside V - a review.
- Author:
Zemin SUN
1
;
Bo LÜ
2
;
Yongjun FENG
1
Author Information
- Publication Type:Review
- Keywords: biosynthesis; mogroside V; natural nonsugar sweetener; synthetic biology
- MeSH: Biological Products/chemistry*; Sweetening Agents/chemical synthesis*; Synthetic Biology; Triterpenes/chemical synthesis*
- From: Chinese Journal of Biotechnology 2020;36(10):2017-2028
- CountryChina
- Language:Chinese
- Abstract: Mogroside V, a component with high content and sweetness in mogrosides, has many pharmacological activities such as relieving cough, reducing sputum, anti-cancer, anti-oxidation, regulating blood sugar, making it a natural nonsugar sweetener with therapeutic functions, and showing a broad market prospect. However, the limited resources and high extraction costs have restricted its widespread use. The rapid development of synthetic biology has provided a new idea for the production of plant natural products. The low-cost and large-scale production will be realized through the construction of a microbial cell factory for mogroside V. Here, we briefly introduce the structure and pharmacological activity of mogroside V, and review progress in applying synthetic biology for its synthesis, and also discuss the challenges faced by the current research, to provide a reference for further studies on the biosynthesis of mogroside V.
