Research progress of Pictet-Spenglerases.
- Author:
Yunchang XIE
1
;
Qi CHEN
2
;
Shaofei ZHANG
3
;
Chuanpu SHEN
3
Author Information
- Publication Type:Review
- Keywords: Pictet-Spengler reaction; Pictet-Spenglerase; alkaloid; biocatalysis; biosynthesis
- MeSH: Alkaloids/chemistry*; Catalysis; Enzymes/metabolism*; Research/trends*; Tetrahydroisoquinolines/chemistry*
- From: Chinese Journal of Biotechnology 2020;36(10):2001-2016
- CountryChina
- Language:Chinese
- Abstract: Pictet-Spenglerases (P-Sases) catalyze the Pictet-Spengler (P-S) reactions and exhibit high stereoselectivity and regioselectivity under mild conditions. The typical P-S reaction refers to the condensation and recyclization of β-arylethylamine with aldehyde or ketone under acidic conditions to form tetrahydroisoquinoline and β-carboline alkaloid derivatives. The related enzymatic products of P-Sases are the backbones of various bioactive compounds, including clinical drugs: morphine, noscapine, quinine, berberine, ajmaline, morphine. Furthermore, the activity of P-Sases in stereoselective and regioselective catalysis is also valuable for chemoenzymatic synthesis. Therefore, this review summarizes the research progress in the discovery, functional identification, biological characteristics and catalytic applications of P-Sases, which provide the useful theoretical reference in future P-Sases research and development.
