Exosomal proteomics study in the tumorigenesis, development and treatment of hepatocellular carcinoma.

Liping Zhao; Feng XU; Yali Zhang; Ping XU

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Exosomal proteomics study in the tumorigenesis, development and treatment of hepatocellular carcinoma.

Author: Liping ZHAO ¹ ; Feng XU ² ; Yali ZHANG ¹ ; Ping XU ¹
Author Information

1. School of Medicine, Guizhou University, Guiyang 550025, Guizhou, China.
2. State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Publication Type:Review
Keywords: diagnosis; exosomal proteins; hepatocellular carcinoma; molecular markers; proteomics; treatment
MeSH: Carcinogenesis/genetics*; Carcinoma, Hepatocellular/therapy*; Exosomes/metabolism*; Humans; Liver Neoplasms/therapy*; MicroRNAs/genetics*; Proteomics
From: Chinese Journal of Biotechnology 2020;36(10):1992-2000
CountryChina
Language:Chinese
Abstract: Hepatocellular carcinoma (HCC) is one of the five most common malignant tumors. According to the latest statistics of the World Health Organization (WHO), the incident and mortality rates of HCC ranks the eighth and third in the world, respectively, which severely affect people's health. Exosomes are extracellular vesicles with a bilayer of phospholipids, which carry active substances such as proteins and nucleic acids derived from their mother cells. These exosomes greatly facilitate the exchange of substances and information between cells, and coordinate physiological and pathological processes in the body. In recent years, a large number of studies have shown that exosomal proteins play important roles in the tumorigenesis, development, diagnosis and treatment of HCC. Here we review the composition and functions of exosomes and the role of exosomal proteins in HCC.